Sometimes it feels like we (a cultural, intellectual, perhaps pseudo intellectual we) tired of perceptions unfolding with the movement of the observer and deconstructed simultaneity into meaningless. Before the hey day of relativism, duality was tangled with, but accepted -- and not as rendering the concept of truth meaningless (we can't really know anything, so nothing means anything). Two sides of a coin. Death helps one understand life, or at least the brevity of life (mortality) helps one appreciate the experience of life, come what may afterward.
We have very few real paradigmatic shifts like the one that accompanied modernism (or more particularly, Cezanne, cubism, etc) … we remain subsumed in the age in which relativism/relationships and acute awareness of the limitations of the observer is the underlying operative framework for our thinking about meanings. Still, on the macro day to day level in which we generally operate, ordinary cause and effect has meaning, at least to the the ones who feel the effects: it can't be disregarded. With out the intervention of a surgeon (and perhaps even with it), a bullet to the heart will kill.
Is it possible we are unable to fully articulate/comprehend a universal that nonetheless exists? Can we judge one construct against another without the need for a universal truth? It's easy enough to spout everything is relative, all constructs devolve into power battles, and none is worse or better than the other since there is no universal reality/truth against which to judge the constructs or principles underlying the constructs. But is it really so that some constructs in practice don't leave more people better off than do other constructs long term? Or that some don't offer more mobility to change position than others, as beyond the construct makers who would put themselves in a position of privilege, one does not know beforehand what position one will occupy in a given construct? Or that some constructs do not require ignoring cause and effect (at least probabilistic cause and effect) on a macro level?
If every "reality" we experience/occupy is a construct, with no standard to judge one construct against the other, I'd suggest there are means of questioning the utility, if nothing else, of the construct. Does the construct denies cause and effect on a macro level? What is the construct's internal consistency: does it meet the values it purports to elevate or does it simply devolve into hypocrisy?